TY - JOUR AU - Taskin, Seyhan PY - 2022/07/22 Y2 - 2024/03/28 TI - A New Perspective on the Adaptation and Proliferation Mechanism of Cancer Cells: Atypical kinase eEF-2K: Cancer and eEF-2K JF - International Journal of Current Medical and Biological Sciences JA - İJCMBS VL - 2 IS - 2 SE - Review DO - 10.5281/zenodo.6555602 UR - https://ijcmbs.com/index.php/ijcmbs/article/view/47 SP - 143-149 AB - <p style="font-weight: 400;">Eukaryotic elongation factor 2 kinase (eEF-2K) is a member of the group of atypical α-kinases. eEF-2K, also known as calcium/calmodulin-dependent protein kinase III, is an important regulatory molecule in cellular protein synthesis. eEF-2K can control protein chain elongation rate by phosphorylating/inactivating eukaryotic elongation factor 2 (eEF-2). The activity of eEF-2K is dependent on calcium ions and calmodulin. In addition, its activity is extensively regulated by posttranslational phosphorylation. Recent data show that eEF-2K helps protect cancer cells against nutrient restriction and energy depletion, and is also cytoprotective in many conditions, including oxidative stress and hypoxia. eEF-2K is considered to be a new potential pharmacological target for cancer therapy.</p> ER -