https://ijcmbs.com/index.php/ijcmbs/issue/feed International Journal of Current Medical and Biological Sciences 2022-11-02T19:22:34+03:00 Assoc. Prof. Mustafa Begenc Tascanov info@ijcmbs.com Open Journal Systems <p><strong>The international journal of <span style="font-size: 0.875rem;">current </span>medical and biological sciences (e-ISSN 2791-8815)</strong><span style="font-size: 0.875rem;"> is published in accordance with the principles of independent, impartial and double-blind reviewer. The journal is published 3 times a year. No fee is charged from the authors during the article evaluation and publication process.</span></p> <p>It publishes clinical and experimental studies, editorial articles, technical and educational reviews, clinical case reports, original images, letters to the editor, and congress abstracts that contribute to general medicine and academic studies. It is published as open access in the English language.</p> https://ijcmbs.com/index.php/ijcmbs/article/view/59 Negative Effects of Aflatoxin B1 on Bull Sperm 2022-07-14T19:35:15+03:00 Veysel Doğan d_veysel@yahoo.com <p style="font-weight: 400;">Aflatoxins are secondary metabolites that produced by <em>Aspergillus </em>fungi which are soilborne and involved in the decomposition of plant materials in nature. <em>Aspergillus</em> species find opportunity to produce aflatoxins in high humidity and temperature conditions such as tropical and subtropical environment. Therefore, in changing climatic conditions caused by global warming, geographical distribution of these fungi to have changed day by day, and find out an opportunity to grow in different feed materials. Aflatoxin B1 (AFB1) is the most toxigenic mycotoxin in these group and threatens both human and animal health due to its carcinogenic and mutagenic properties. In cattle, commonly known adverse effects of AFB1 depending on the chronic exposure such as decreasing milk production and quality, reducing the feed efficiency in beef cattle, increase susceptibility to diseases following suppression of the immune system, compromise ruminal functions, disruption of ruminal microorganism growth and functions. In addition, there are limited literatures on adverse effects of AFB1 on the reproduction performance in cattle.</p> <p style="font-weight: 400;">In this study, the negative effects of AFB1 on bull sperm has been examined. Topics such as negative effects of AFB1 on sperm proteomes, increase in the reactive oxygen species, changes in sperm DNA and plasma membrane integrity are discussed. &nbsp;</p> 2022-08-02T00:00:00+03:00 Copyright (c) 2022 International Journal of Current Medical and Biological Sciences https://ijcmbs.com/index.php/ijcmbs/article/view/60 Evaluation of polypharmacy and adherence to the phosphorus binding treatment in hemodialysis patients 2022-08-31T14:31:15+03:00 Nihal Bozdag Kaplan drnihalkaplan@gmail.com Prof. Dr. Nurol ARIK nurarik@superonline.com <p><strong>Background:</strong> Polypharmacy and nonadherence to treatment regimens confront as an ever-mounting problem in hemodialysis patients. The aim of the present study was to emphasize the importance of polypharmacy and tablet load problem and to evaluate the adherence to phosphorus binding agent treatment and to examine the factors that cause to non-adherence.</p> <p><strong>Material and Method:</strong> 361 patients who were in regular dialysis program in 4 different hemodialysis centers in Samsun city were included in the study. By meeting face to face, a questionnaire that was composed of 35 questions which investigated the factors that effect the polypharmacy and treatment adherence was filled to patients by a physician. Adherence to phosphorus binding treatment was measured according to both serum phosphorus level and Modified Morisky Adherence Scale.</p> <p><strong>&nbsp;Results</strong>: In hemodialysis patients, the mean daily used drug groups were found as 5, the tablet count was found as 10. It was determined that the phosphorus levels of % 40.4 of patients who were using phosphorus binding agents were found above the target phosphorus level that was recommended in the guidelines. According to the adherence questionnaire that was performed to the patients, non-adherence rate to the phosphorus binding agents was found 77,3 %. In addition, age, educational background, smoking and tablet load are the factors that were not found effective on the adherence to the phosphorus binding agents treatment .</p> <p>&nbsp;</p> <p><strong>Conclusion: </strong>Polypharmacy and non-adherence to the phosphorus binding treatment are serious and worth-stressing problems that should be solved in hemodialysis patients. We think that more, more advanced and quality research is needed to improve adherence on this subject</p> 2022-09-21T00:00:00+03:00 Copyright (c) 2022 International Journal of Current Medical and Biological Sciences https://ijcmbs.com/index.php/ijcmbs/article/view/64 Determination of dry tibia bone morphometry by photo analysis 2022-10-08T00:07:10+03:00 Seyma Toy seymatoy44@gmail.com Yusuf Secgin yusufsecgin@karabuk.edu.tr <p><strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">Amaç:</span></span></strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"> Bu çalışma, foto analiz yöntemi ile belirlenen kuru tibia kemiği parametrelerinin morfometrik analizini göstermek amacıyla yapılmıştır.</span></span></p> <p><strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">Malzemeler ve yöntemler:</span></span></strong>33 dry tibia bones in the bone collection of 3 universities were included in the study. Disintegrated and deformed dry tibia bones were excluded from the study. The bones obtained were positioned at a height of 40 cm with the help of a stabilizer on a guide scale with spaces of 1 cm, while the professional camera was positioned 60 cm high. The photos were transferred to image processing program Image J (Version 1.53e) in jpeg format. From the images transferred, the parameters of width of medial condyle (MC-W), height of medial condyle (MC-H), width of lateral condyle (LC-W), height of lateral condyle (LC-H), distance between medial and lateral intercondylar tubercle (LMIT-D), width of body of tibia (BT-W), length of total tibia (TT-L), height of medial malleolus (MM-H), angle of medial condyle- tibial tuberosity-lateral condyle (MCTTLG-A), angle of fibular notch - tibial tuberosity- medial malleolus (FNTTMM-A), height of inferior articular facet (IAS-H), width of inferior articular facet (IAS-W), distance between nutrient foramen- interosseous border (NFIB-D) were measured.</p> <p><strong>Background: </strong>This study was carried out to determine the morphometry of the dry tibia bones of the Turkish population using the photo analysis method.</p> <p><strong>Materials and Methods: </strong>33 dry tibia bones were included in the study. The bones obtained were photographed with a professional camera. The photos were transferred to image processing program Image J (Version 1.53e) in jpeg format. From the images transferred, the parameters of articular surface width of medial condyle (MC-ASW), articular surface height of medial condyle (MC-ASH), articular surface width of lateral condyle (LC-ASW), articular surface height of lateral condyle (LC-ASH), distance between medial and lateral intercondylar tubercle (LMIT-D), medium width of body of tibia (BT-MW), length of total tibia (TT-L), height of medial malleolus (MM-H), angle of medial condyle- tibial tuberosity-lateral condyle (MCTTLG-A), angle of fibular notch - tibial tuberosity- medial malleolus (FNTTMM-A), height of inferior articular facet (IAS-H), width of inferior articular facet (IAS-W), distance between nutrient foramen- interosseous border (NFIB-D) were measured. <strong>Results: </strong>Morphometric analysis results were: MC-ASW 6.558±0.896 cm, MC-ASH 9.502±1.364 cm, LC-ASW 6.035±0.988 cm, LC-ASH 8.655±1.673 cm, LMIT-D 3.169±0.632 cm, BT-MW 2.382±0.312 cm, TT-L 36.784±2.734 cm, MM-H 1.296±0.209 cm, MCTTLG-A 97.14±11.63°, FNTTMM-A 7.313±0.514°, IAS-H 6.219±0.776 cm, IAS-W 6.540±1.011 cm, NFIB-D 0.958±0.326 cm. A statistically significant correlation was found between MC-ASW and MC-ASH, LC-ASW, LC-ASH parameters, between MC-ASH and LC-ASH, TT-L parameters, and between BT-MW and TT-L parameters (p ≤0.05). <strong>Conclusion:</strong> As a result of our study, the morphometry of the parameters of the dry tibia bone in the Turkish population and the relationships between these parameters were revealed.</p> <p><strong>Keywords: </strong>Dry tibia bone, Morphometry, Photo analysis</p> 2022-10-15T00:00:00+03:00 Copyright (c) 2022 International Journal of Current Medical and Biological Sciences https://ijcmbs.com/index.php/ijcmbs/article/view/66 Newly defined Unbalanced distributions of paternal balanced chromosomal translocation and review of the literatüre 2022-10-06T19:09:07+03:00 Şenol Çitli drsenolcitli@gmail.com <p>Balanced chromosomal rearrangements (BCR) are rearrangements with no loss or gain of genetic material and usually not associated with clinical abnormalities. However, BCR carriers may have children with a chromosomal anomaly as a result of an unbalanced transfer of chromosomes to the offsprings. The individuals with unbalanced translocations may exhibit congenital anomalies. Two boys with unbalanced translocation and multiple congenital anomalies of a father with a balanced chromosomal translocation of 46,XY.ish t(5;7)(p15-,q36+;q36-,p15+) and a mother with a 46,XX normal chromosome structure were presented. Partial deletion in 5p and partial duplication in 7q (arr[GRCh37] 5p15.33-p15.2x1, 7q36.1-q36.3x3) in one sibling, and partial duplication in 5p and partial deletion in 7q (arr[GRCh37] 5p15.33-p15.2x3, 7q36.1-q36.3x1) in the other sibling were detected. To the best of our knowledge, 5p partial trisomy+7q partial monosomy and 5p partial monosomy+7q partial trisomy have not been previously reported.</p> 2022-10-22T00:00:00+03:00 Copyright (c) 2022 International Journal of Current Medical and Biological Sciences https://ijcmbs.com/index.php/ijcmbs/article/view/61 Breast glanduler dose and effectiveness of in-plane bishmut breast shield in routine pediatric female chest CT examination 2022-09-13T21:06:34+03:00 Osman Dere drderectf@hotmail.com <p><strong>Background: </strong>The aim of our study is to calculate the radiation dose to which the breast is exposed in pediatric female undergoing routine thoracic multislice computed tomography (MSCT) and to investigate the effectiveness of bismuth shielding in reducing this dose.</p> <p><strong>Materials and Methods: </strong>Twenty patients who were referred to the radiology department for routine thorax MSCT between January 2012 and April 2012 were included in the study. All CT scans were performed with a 128-channel MSCT device (Siemens Somatom Definition AS Siemens AG, Medical Solutions ,Computed Tomography, Forcheim, Germany). A Thermolucent dosimeter (TLD) (3x3x1mm; Harshaw Lif TLD-100; Saint-Gobain Industrial Ceramics, Solon, Ohio) was placed on both breast skins of the patients to measure the radiation dose. A in-plane bismuth breast shield was placed on the right breast, and the left breast was chosen as the unshielded side. Radiation doses in the shielded and unshielded breast were calculated and compared using the Paired-t test.</p> <p><strong>Results: </strong>The mean radiation doses were calculated as 7.0075 mSv and 9.0730 mSv for the shielded right breast and the unshielded left breast, respectively. It was found that in-plane bismuth breast shielding could lower the radiation dose to the right breast by 22.76 %.The difference between the radiation doses of the shielded side of the breast and the unshieldeded side was found to be significant (p&lt;0.001). No deterioration was detected in the image quality of the lung parenchyma on the side where bismuth shielding was placed.</p> <p><strong>Conclusions: </strong>In-plane bismuth shielding significantly reduces the radiation dose of the breast in pediatric female undergoing routine thoracic MSCT examination without impairing the image quality.</p> 2022-11-02T00:00:00+03:00 Copyright (c) 2022 International Journal of Current Medical and Biological Sciences https://ijcmbs.com/index.php/ijcmbs/article/view/67 Comparison of the effects of Propofol, Dexmedetomidine and Midazolam on Sedation and Oxidative-Antioxidant System in Critically ill Patients 2022-10-19T15:28:11+03:00 Mehmet Kenan Erol kenanerol970@gmail.com <p><strong>Purpose: </strong>This study aimed to compare the impact of midazolam, propofol, dexmedetomidine infusions for 24<sup>th</sup> hour on total antioxidant status (TAS), total oxidant status (TOS), oxidative stres index (OSI) and prolidase levels.</p> <p><strong>Material/Metots:</strong> 75 patient ICU patient who were mechanically ventilated enrolled to the study. Patients randomised to three groups. Group I (n=25, midazolam): 0.02 mg/ kg/h midazolam, Group II (n = 25, propofol): 1mg/kg/h propofol, Group III (n=25, dexmedetomidine): 0.2 µg/ kg/h dexmedetomidine infusions was started. Dosage were arrange to achieve Ramsay sedation score 3. Blood samples were collected in basal, 6.,12.,18., 24. hour, and hemodynamic parameters were also recorded in the same time intervals.</p> <p><strong>Results:</strong> In midazolam group 24. hour TAS levels were significantly decreased and TOS, prolidase and OSI levels were significantly increased compared to the basal level (p&lt;0.05). 24. hour TAS levels were significantly decreased and TOS, prolidase and OSI levels were significantly increased compared to basal level in propofol group (p&lt;0,05). In dexmedotimidine groups 24.hour TAS and prolidase levels were significantly decreased, OSI levels were increased compared to the basal levels (p&lt;0.05). Increase in TOS levels were not statistically significant (p&gt;0.05). Basal TAS, TOS, prolidase, OSI levels were not statistically significantly between the different groups (p&gt;0.05).</p> <p><strong>Conlusions:</strong> According to the study results, there were no statistically significant differences between the groups. Among hemodynamic parameters Dexmedetomidine was found to be having statistically significant favorable results in comparison to others. However &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;there results should be clinically and molecularity verified with large scale further studies</p> 2022-10-22T00:00:00+03:00 Copyright (c) 2022 International Journal of Current Medical and Biological Sciences https://ijcmbs.com/index.php/ijcmbs/article/view/69 Relationship between Coronavirus Disease and Erythrocyte Morphology Parameters 2022-10-15T13:09:50+03:00 İbrahim Halil YASAK dr_ihy@hotmail.com Mustafa Yılmaz drmylmz@hotmail.com Eyyup Sabri Şeyhanlı eyyup-1976@windowslive.com Ataman Gönel atamangonel@gmail.com <p><strong>Abstract</strong></p> <p><strong>Background: </strong>To determine the rates of Microcytosis (%), Macrocytosis (%), Hypochromia (%), and Hyperchromia (%) as erythrocyte morphological parameters in COVID-19 infection, using a new-generation hematological autoanalyser, and to evaluate the use of these parameters for diagnostic purposes.</p> <p><strong>Material and Method: </strong>This retrospective study included 66 patients (F:41, M:25) with COVID-19 infection confirmed by real-time PCR test positivity, and 67 age and gender-matched healthy individuals (F:40, M:27) as a control group. The COVID-19 patients were separated into two groups as those with pulmonary infiltration (n=35, F/M:20/15) and those without (n=31, F/M:21/10). The hematological parameters measured on the autoanalyzer were analyzed and compared between the groups.</p> <p><strong>Results: </strong>Age and gender distribution were similar in both study groups (p=0.619, p=0.457). The White Blood Cell (p=0.040) Neutrophil (p&lt;0.001), Lymphocyte (p&lt;0.001), and Platelet (p &lt;0.001) levels were statistically significantly lower in the COVID-19 patients compared to the control group and CRP levels were significantly increased (p&lt;0.001). In the comparisons of the erythrocyte morphology parameters, &nbsp;Microcytosis % (p=0.011) was significantly greater, and &nbsp;Macrocytosis % (p=0.009) and Hypochromia % (p=0.032) were significantly lower in the COVID-19 patients. An increase was determined in &nbsp;Hyperchromia %, but not at a statistically significant level (p=0.059).</p> <p><strong>Conclusion: </strong>From the erythrocyte morphological findings determined with the new-generation devices, the Microcytosis percentage was determined to be significantly increased in COVID-19-positive patients, and this parameter was found to have 78.79% sensitivity and 50.75% specificity in the differentiation of COVID-19 patients from healthy individuals</p> 2022-11-04T00:00:00+03:00 Copyright (c) 2022 International Journal of Current Medical and Biological Sciences https://ijcmbs.com/index.php/ijcmbs/article/view/70 Burnout Syndrome In Urology Residents: A Multicenter Survey Study 2022-11-02T19:22:34+03:00 İsmail Evren drevrenis@hotmail.com Ubeyd Sungur ubeydsungur@gmail.com Mithat Ekşi mithat_eksi@hotmail.com Taner Kargı tanerkargi83@hotmail.com Yusuf Arıkan dryusufarikan@gmail.com Ali Timuçin Atayoğlu atatayoglu@medipol.edu.tr Ferhat Yakup Suçeken ykpsckn@gmail.com <p><strong>Background: </strong>Many physicians experience professional burnout. The aim of this study is to determine the level of burnout syndrome in residents receiving urology training and determine factors that may cause it.</p> <p><strong>Materials and Methods: </strong>A cross-sectional descriptive study.A survey containing questions on sociodemographic characteristics and the Maslach Burnout Inventory were administered to 46 urology residents in different years of residency training at different clinics.</p> <p><strong>Results: </strong>The mean age of the urology residents participating in the study was 29.0±2.1 years. The majority of the participants were not satisfied with the work-social life balance and reported that they did not have sufficient time to spare for personal lives. It was determined that most participants had high scores in the Maslach Burnout Inventory subscales. The mean subscales scores of the participants were determined as 24.7 ± 6.3 for emotional exhaustion, 11 ± 3.4 for depersonalization, 19.2 ± 4.1 personal achievement. When the residents’ sociodemographic characteristics, such as marital status, whether they were at the beginning or end of their residency training, smoking status, and alcohol consumption habits were separately examined, there was no significant difference in the Maslach Burnout Inventory subscale scores according to these variables (p&gt;0.05). However, the participants who reported that they would not choose urology again if they were given the opportunity to change their specialty had statistically significantly higher scores in the emotional exhaustion and depersonalization subscales compared to those stated that they would have made the same choice (p = 0.001 and p = 0.02, respectively).</p> <p><strong>Conclusion: </strong>Burnout syndrome is frequently seen in residents undergoing urology specialty training. There is a need to carefully determine causes of burnout syndrome and establish policies that will increase the motivation of urology residents. It is important to determine how to spot it and take action with a multidisciplinary approach from primary healthcare to occupational healthcare.</p> <p><strong>Keywords: </strong>Burnout syndrome, Urology, Resident, Primary healthcare, Occupational healthcare</p> 2022-11-14T00:00:00+03:00 Copyright (c) 2022 International Journal of Current Medical and Biological Sciences https://ijcmbs.com/index.php/ijcmbs/article/view/75 RELATIONSHIP OF HUMERUS RETROVERSION ANGLE WITH MORPHOMETRIC PARAMETERS 2022-10-26T07:56:01+03:00 GAMZE TAŞKIN ŞENOL rumeysagamzetaskin@ibu.edu.tr İbrahim KÜRTÜL ibrahimkurtul@ibu.edu.tr Abdullah Ray abdullahray10@gmail.com Gülçin Ahmetoğlu g.ahmetoglu00@gmail.com <p><strong>Aim:</strong> This study aims to perform a detailed analysis of the morphometric anatomical measurements of the humerus to make clinically successful and accurate evaluations.</p> <p><strong>Material and Method:</strong> A total of 42 dry bone humerus, 23 left and 19 right, were included in the study. Measurement parameters: Humerus length (LH), surgical neck circumference (CSN), sulcus intertubercularis width (WIS), sulcus intertubercularis depth (DIS), epicondylar width (WE), trochlea humeri width (WTH), fossa olecranii width (WOF), fossa olecranii depth (DOF), transverse diameter of the humeral head (TDH), vertical diameter of the humeral head (VDH), minimum corpus diameter (MinDS), maximum corpus diameter (MaxDS), capitulum humeri width (WS), capitulum humeri length (LC), trochlea humeri length (LTH), coronoideal arch height (HCA), coronoideal arch width (WCA), fossa olecranii height (HOF), humeral retroversion angle (RAH) were determined.</p> <p><strong>Results:</strong> According to the study results, mean and standard deviation values, LH; 300, CSN; 72±8.7, WIS; 8.2±1.6, DIS; 5.7±0.9, WE; 59, WTH; 15.6±4.4, WOF; 22.7±2.2, DOF; 13.4±2.1, TDH; 42.5±2.8, VDH; 44.8±3.5, MinDS; 18.7±1.8, MaxDS ; 21.8±2.1, WS; 16.2±4.1, LC; 20.6±1.7, LTH; 20.7±4.4, HCA; 6.3, WCA; 11, HOF; 13,4±2.2, RAH; 28.2.</p> <p><strong>Conclusion:</strong> It is very important to calculate the average values ​​of the anatomical structures in this bone to know the humerus bone's normal anatomical structure and to guide the surgical procedures and prosthesis applications in this region. The detailed data obtained as a result of the study support the literature findings. The results of the study will make a qualified contribution to forensic and anthropological research on the humerus.</p> 2022-11-14T00:00:00+03:00 Copyright (c) 2022 International Journal of Current Medical and Biological Sciences https://ijcmbs.com/index.php/ijcmbs/article/view/71 Metastasis of Renal Cell Carcinoma to the Urinary Bladder: Case Report 2022-10-25T08:26:18+03:00 Murat Çağlayan drmuratcaglayan@gmail.com <p>Distant metastasis is seen in 30% of patients with Renal Cell Carcinoma at the time of diagnosis. In this study, we aimed to present two very rare cases of bladder metastases. Case 1; A 65-year-old male patient with nodular thickening and mass in the bladder wall around the right ureteral orifice. Case 2; The patient, who had undergone nephrectomy operation due to a mass in the left kidney, was hospitalized with the complaint of hematuria and a mass in the bladder was detected in the examination.Although metastasis of Renal Cell Carcinoma to the bladder is not common, it should be kept in mind in routine control examinations and investigated for metastasis.</p> 2022-11-14T00:00:00+03:00 Copyright (c) 2022 International Journal of Current Medical and Biological Sciences