The Role Of Amıno Acıds In Knee Osteoarthrıtıs

Amıno Acıds In Knee Osteoarthrıtıs

Abstract

Backgrounds

Osteoarthritis is an important public health problem and the most common musculoskeletal disease in the World. The pathogenesis and etiology of osteoarthritis is still unclear. We aimed to make an Amino acids analysis that will contribute to the pathogenesis, diagnosis and treatment of knee osteoarthritis.

Methods

The study included according to the radiological grading scale of Kellgren-Lawrence, 30 patients at Grade 1-2; Group 1 (Grade 1-2), 30 patients at Grade 3-4; Group 2 (Grade 3-4), 30 healthy controls; Group 3. We compared between groups age, sex, body mass index, Western Ontario and McMaster Universities, Short form-36 findings, and plasma-free amino acid levels.

Results

A comparison of the serum norvaline, leucine, isoleucine, allo-isoleucine, cystathionine, phenylalanine, 1-methyl hystidine, arginine, alanine, cystine, valine, threonine, and tryptophane levels of the knee osteoarthritis and control groups compared a statistically significant difference (p=0.000, p=0.000, p=0.000, p=0.000, p=0.044, p=0.003, p=0.000, p=0.035, p=0.010, p=0.011, p=0.000, p=0.000, p=0.003).

Conclusions

We consider that, norvaline leucine; isoleucine, allo-isoleucine, cystathionine, phenylalanine, 1-methyl hystidine, arginine, alanine, cystine, valine, threonine, and tryptophane amino acids could be, as potential systemic serum biomarkers for diagnosis of knee osteoarthritis.