Does the eosinophil-to-monocyte ratio predict inflammation in patients with diabetic retinopathy

Diabetic retinopathy and Eosinophil-to-monocyte ratio

Abstract

Backgruond: Our purpose is to investigate the demographic, clinical and haematological parameters of patients diagnosed with diabetic retinopathy (DRP) without coronary artery disease and control group

Materials and Method:  This study was retrospective and the information of all patients was retrospectively scanned and their anamnesis was noted from the medical record files. A total of 151 patients, 75 with DRP and 76 in the control group without diabetes and a history of coronary artery disease, were included in the study. For all statistics, a p-value below 0.05 was considered significant.

Results: There was no distinction between the DRP and the other group in terms of clinical and demographic features. The serum glucose (p<0.001), creatinine (p=0.029), and triglyceride (p=0.047) were higher in patients with the DRP group However, eosinophil level (p=0.009) and eosinophil-to-monocyte ratio (EMR) (p=0.003) values were lower in DRP patients. Multivariable linear regression analyses showed serum glucose (OR:1.241, 95% CI [1.087 – 1.418], p<0.001) and EMR (OR:0.966, 95% CI [0.440–2.117], p= 0.030) were potential risk factors for DRP.

Conclusion: In our research, we observed that the serum eosinophil level and EMR in patients with DRP were lower than in other patients and that this, together with the high glucose level, had an independent predictive value for DRP. Future large-scale studies will shed light on this topics.